12-Column DNA Synthesizer
12 oligonucleotide syntheses in one run

Minimal space requirement

The compact design
41 x 43 x 40 cm (LxDxH)
means that a small area only
is required.

  20 % higher flow-rate
  modified drive system for
    high flow-rate
  8 Amidite positions
  3 additional inlets for

Suitable for creating RNA, LNA
and premixed Wobbles

Upon customer’s request housings
can be printed with individual designs.


The advantages of the PolyGen Synthesizer:

Minimal reagent consumption

  • Extremely economical in reagent consumption due to the patented
    Slider Block
    of low dead volume (ca. 3 µl).
    In the fast program:
    only 0.6 ml total solvent consumption per coupling
    In the high-quality program:
    only 1.1 ml total solvent consumption per coupling
  • Measurement of reagent addition is by integrated metering pump
  • Variable flow rates and times in each individual program step

No expensive pre-packed columns necessary

  • Costly consumables such as pre-packed columns become unnecessary
    as the reaction vessels are integrated in the Slider Block system
  • The CPG materials are directly fed into the column slider.

Wide synthesis range

  • From 10 nmole - 1 µmole per column.
  • From 1 µmole - 5 µmole with separate Slider

Short synthesis times

  • 12 couplings in 6 minutes - 12 oligo-syntheses in one run
    (12-Column DNA Synthesizer).
  • 20-unit Poly-T in 1h 45 min using the fast program and up to 2 h 55 min
    using the high-quality program.

High degree of user-friendliness and ease of maintenance

  • No valve replacement required.
  • Maintenance-free due to patented Slider Block system.
  • Service and maintenance contracts unnecessary.

Direct data transfer from PC

  • The 12-Column DNA Synthesizer can be operated as a stand-alone
    instrument or with various software suites via PC.
  • Thus the direct transfer of sequences from your database into
    the synthesizer is possible.

Flexible, user-oriented software

DMT system for reliable process monitoring

  • Each individual column can be monitored by DMT; the entire synthesis process is thus constantly under review. If the minimum required absorption is not achieved, a warning signal is given; alternatively,
    the process can be stopped.
  © PolyGen GmbH® - Experiences & know-how since 1990 in development & manufacturing DNA synthesizers